Paper Info
Title
Secret4: A Web-Based Bacterial Type Iv Secretion System Resource
Abstract
SecReT4 ( http://db-mml.sjtu.edu.cn/SecReT4/) is an integrated database providing comprehensive information of type IV secretion systems (T4SSs) in bacteria. T4SSs are versatile assemblages that promote genetic exchange and/or effector translocation with consequent impacts on pathogenesis and genome plasticity. T4SSs have been implicated in conjugation, DNA uptake and release and effector translocation. The effectors injected into eukaryotic target cells can lead to alteration of host cellular processes during infection. SecReT4 offers a unique, highly organized, readily exploreable archive of known and putative T4SSs and cognate effectors in bacteria. It currently contains details of 10 752 core components mapping to 808 T4SSs and 1884 T4SS effectors found in representatives of 289 bacterial species, as well as a collection of more than 900 directly related references. A broad range of similarity search, sequence alignment, phylogenetic, primer design and other functional analysis tools are readily accessible via SecReT4. We propose that SecReT4 will facilitate efficient investigation of large numbers of these systems, recognition of diverse patterns of sequence-, gene- and/or functional conservation and an improved understanding of the biological roles and significance of these versatile molecular machines. SecReT4 will be regularly updated to ensure its ongoing maximum utility to the research community.
Year
DOI
Venue
2013
10.1093/nar/gks1248
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
internet,bacteria
Sequence alignment,Genome,Molecular machine,Gene,Biology,Secretion,DNA,Effector,Primer (molecular biology),Genetics
Journal
Volume
Issue
ISSN
41
D1
0305-1048
Citations 
PageRank 
References 
10
0.77
8
Authors
6
Name
Order
Citations
PageRank
Dexi Bi1192.27
Linmeng Liu2100.77
Cui Tai3304.19
Zixin Deng4395.74
Kumar Rajakumar5323.48
Hong-Yu Ou6395.69