Name
Title | ||
|---|---|---|
Evolution of gene families based on gene duplication, loss, accumulated change, and innovation. |
Abstract | ||
|---|---|---|
We introduce and analyze a simple discrete probabilistic model of genome evolution. It is based on four fundamental evolutionary events: gene (d) under bar uplication, (l) under bar oss, accumulated (c) under bar hange and innovation. We call it the DLCI model. It is the first such model rigorously analyzed. The focus of the paper is on the size distribution of gene families. We derive formulae for the equilibrium of gene family sizes, and show that they follow a logarithmic distribution. We also consider a disjoint union of DLCI models and present empirical results for bacterial genomes. |
Year | DOI | Venue |
|---|---|---|
2007 | 10.1089/cmb.2007.A008 | JOURNAL OF COMPUTATIONAL BIOLOGY |
Keywords | Field | DocType |
gene family size distribution,genome evolution,Markov chains,paralogous genes | Biology,Markov chain,Genome evolution,Statistical model,Bioinformatics,Gene duplication,Disjoint union,Gene family,Bacterial genome size,Logarithmic distribution | Journal |
Volume | Issue | ISSN |
14.0 | 4 | 1066-5277 |
Citations | PageRank | References |
2 | 0.52 | 6 |
Authors | ||
2 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Damian Wójtowicz | 1 | 10 | 4.40 |
| Jerzy Tiuryn | 2 | 1210 | 126.00 |