Paper Info
Title
Modelling of Tirapazamine Effects on Solid Tumour Morphology.
Abstract
Bioreductive drugs are in clinical practice to exploit the resistance from tumour microenvironments especially in the hypoxic region of tumour. We presented a tumour treatment model to capture the pharmacology of one of the most prominent bioreductive drugs, Tirapazamine (TPZ) which is in clinical trials I and II. We calculated solid tumour mass in our previous work and then integrated that model with TPZ infusion. We calculated TPZ cytotoxicity, concentration, penetration with increasing distance from blood vessel and offered resistance from microenvironments for drug penetration inside the tumour while considering each cell as an individual entity. The impact of these factors on tumour morphology is also showed to see the drug behaviour inside animals/humans tumours. We maintained the heterogeneity factors in presented model as observed in real tumour mass especially in terms of cells proliferation, cell movement, extracellular matrix (ECM) interaction, and the gradients of partial oxygen pressure (pO2) inside tumour cells during the whole growth and treatment activity. The results suggest that TPZ high concentration in combination with chemotherapy should be given to get maximum abnormal cell killing. This model can be a good choice for oncologists and researchers to explore more about TPZ action inside solid tumour.
Year
DOI
Venue
2011
10.1007/978-3-642-19914-1_18
5TH INTERNATIONAL CONFERENCE ON PRACTICAL APPLICATIONS OF COMPUTATIONAL BIOLOGY & BIOINFORMATICS (PACBB 2011)
Keywords
Field
DocType
AQ4N,Extra Cellular Matrix,Hypoxia and Tirapazamine
Solid tumour,Cell movement,Cytotoxicity,Tirapazamine,Biology,Chemotherapy,Clinical Practice,Pharmacology,Cell,Extracellular matrix
Conference
Volume
ISSN
Citations 
93
1867-5662
0
PageRank 
References 
Authors
0.34
2
3
Name
Order
Citations
PageRank
Nabila Kazmi100.34
M. Alamgir Hossain210716.52
Roger M. Phillips320.73