Name
Title | ||
|---|---|---|
Abnormalities in neural processing of emotional stimuli in Williams syndrome vary according to social vs. non-social content. |
Abstract | ||
|---|---|---|
Williams syndrome (WS) is a rare genetic disorder caused by the deletion of ∼25 genes on chromosome 7q11.23 and is characterized by both hypersociability and increases in specific phobia and anticipatory anxiety regarding non-social entities or circumstances. Alterations in amygdala reactivity and prefrontal regulation consistent with the observed behavioral pattern of social versus non-social abnormalities have been previously demonstrated in individuals with WS (Meyer-Lindenberg et al., 2005). However, in that study, the social stimulus (faces) matching task was more difficult than the non-social scene (IAPS stimuli) matching task, making it impossible to disambiguate the relative contributions of task difficulty and stimulus type (social versus non-social). In the present study, we examined the performance of the same group of participants with WS and normal IQs during a more cognitively demanding task using the same scene stimuli as in the prior study. Confirming previous findings, the results indicated (a) a differential response of prefrontal regions as a function of task difficulty and (b) a persistently increased activation of the amygdala to non-social scenes by individuals with WS regardless of cognitive load. These data provide further evidence of disruption in amygdala-prefrontal circuitry in individuals with WS. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.1016/j.neuroimage.2009.11.069 | NeuroImage |
Keywords | Field | DocType |
cognitive load | Williams syndrome,Brain mapping,Developmental psychology,Hypersociability,Prefrontal cortex,Psychology,Cognitive psychology,Amygdala,Specific phobia,Stimulus (physiology),Cognition | Journal |
Volume | Issue | ISSN |
50 | 1 | 1053-8119 |
Citations | PageRank | References |
2 | 0.48 | 5 |
Authors | ||
7 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Karen E. Muñoz | 1 | 2 | 0.48 |
| Andreas Meyer-Lindenberg | 2 | 253 | 18.54 |
| Ahmad R. Hariri | 3 | 9 | 2.69 |
| Carolyn B. Mervis | 4 | 2 | 0.48 |
| Venkata S. Mattay | 5 | 87 | 19.18 |
| Colleen A. Morris | 6 | 2 | 0.48 |
| Karen Faith Berman | 7 | 11 | 3.26 |