Paper Info
Title
BioSig: a Bioinformatic System for Studying the Mechanism of Inter-Cell Signaling
Abstract
Mapping inter-cell signaling pathways requires an integrated view of experimental and informatic protocols. BioSig provides the foundation of cataloging inter-cell responses as a function of particular conditioning, treatment, staining, etc. for either in vivo or in vitro experiments. This paper outlines the system architecture, a functional data model for representing experimental protocols, algorithms for image analysis, and the required statistical analysis. The architecture provides remote shared operation of an inverted optical microscope, and couples instrument operation with images acquisition and annotation. The information is stored in an object-oriented database. The algorithms extract structural information such as morphology and organization, and map it to functional information such as inter-cellular responses. An example of usage of this system is included.
Year
DOI
Venue
2000
10.1109/BIBE.2000.889619
BIBE
Keywords
Field
DocType
bioinformatic system,mapping inter-cell,required statistical analysis,functional information,structural information,experimental protocol,inter-cell signaling,couples instrument operation,image analysis,functional data model,remote shared operation,inter-cell response,morphology,staining,informatics,system architecture,in vivo,statistical analysis,cell signaling,in vitro,bioinformatics,image processing,algorithms,optical microscope,optical microscopy,protocols,data transmission,data models,performance,conditioning
Data mining,Annotation,Data transmission,Computer science,Image processing,Cataloging,Artificial intelligence,Cell signaling,Systems architecture,Functional data model,Machine learning,Statistical analysis
Conference
ISBN
Citations 
PageRank 
0-7695-0862-6
6
0.91
References 
Authors
8
6
Name
Order
Citations
PageRank
B. Parvin120319.16
G. Cong215018.05
gerald v fontenay3193.11
jeremy m g taylor460.91
R. Henshall560.91
Mary Helen Barcellos-Hoff6969.15