Name
Title | ||
|---|---|---|
Detecting and understanding genetic and structural features in HIV-1 B subtype V3 underlying HIV-1 co-receptor usage. |
Abstract | ||
|---|---|---|
To define V3 genetic elements and structural features underlying different HIV-1 co-receptor usage in vivo.By probabilistically modeling mutations in the viruses isolated from HIV-1 B subtype patients, we present a unique statistical procedure that would first identify V3 determinants associated with the usage of different co-receptors cooperatively or independently, and then delineate the complicated interactions among mutations functioning cooperatively. We built a model based on dual usage of CXCR4 and CCR5 co-receptors. The molecular basis of our statistical predictions is further confirmed by phenotypic and molecular modeling analyses. Our results provide new insights on molecular basis of different HIV-1 co-receptor usage. This is critical to optimize the use of genotypic tropism testing in clinical practice and to obtain molecular-implication for design of vaccine and new entry-inhibitors. |
Year | DOI | Venue |
|---|---|---|
2013 | 10.1093/bioinformatics/btt002 | Bioinformatics |
Keywords | Field | DocType |
structural feature,dual usage,hiv-1 b subtype patient,v3 genetic element,v3 determinant,hiv-1 co-receptor usage,ccr5 co-receptors,molecular modeling analysis,molecular basis,new entry-inhibitors,different co-receptors,mutation,genotype | Co-receptor,Genotype,Tropism,Phenotype,Biology,Clinical Practice,Bioinformatics,Mutation | Journal |
Volume | Issue | ISSN |
29 | 4 | 1367-4811 |
Citations | PageRank | References |
0 | 0.34 | 3 |
Authors | ||
12 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Mengjie Chen | 1 | 0 | 0.34 |
| Valentina Svicher | 2 | 10 | 2.28 |
| Anna Artese | 3 | 3 | 1.17 |
| Giosuè Costa | 4 | 8 | 1.26 |
| Claudia Alteri | 5 | 0 | 0.34 |
| Francesco Ortuso | 6 | 26 | 4.19 |
| Lucia Parrotta | 7 | 0 | 0.34 |
| Liu Yang | 8 | 200 | 33.54 |
| Chang Liu | 9 | 15 | 7.17 |
| Carlo Federico Perno | 10 | 3 | 0.83 |
| Stefano Alcaro | 11 | 31 | 5.73 |
| Jing Zhang | 12 | 2 | 1.04 |