Paper Info
Title
Mimodb 2.0: A Mimotope Database And Beyond
Abstract
Mimotopes are peptides with affinities to given targets. They are readily obtained through biopanning against combinatorial peptide libraries constructed by phage display and other display technologies such as mRNA display, ribosome display, bacterial display and yeast display. Mimotopes have been used to infer the protein interaction sites and networks; they are also ideal candidates for developing new diagnostics, therapeutics and vaccines. However, such valuable peptides are not collected in the central data resources such as UniProt and NCBI GenPept due to their 'unnatural' short sequences. The MimoDB database is an information portal to biopanning results of random libraries. In version 2.0, it has 15 633 peptides collected from 849 papers and grouped into 1818 sets. Besides the core data on panning experiments and their results, broad background information on target, template, library and structure is included. An accompanied benchmark has also been compiled for bioinformaticians to develop and evaluate their new models, algorithms and programs. In addition, the MimoDB database provides tools for simple and advanced searches, structure visualization, BLAST and alignment view on the fly. The experimental biologists can easily use the database as a virtual control to exclude possible target-unrelated peptides. The MimoDB database is freely available at http://immunet.cn/mimodb.
Year
DOI
Venue
2012
10.1093/nar/gkr922
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
sequence alignment
Ribosome display,Bacterial display,Biology,UniProt,Phage display,Biopanning,Mimotope,Molecular biology,Database,Yeast display,mRNA display
Journal
Volume
Issue
ISSN
40
D1
0305-1048
Citations 
PageRank 
References 
8
0.91
12
Authors
10
Name
Order
Citations
PageRank
Jian Huang12608200.50
Beibei Ru2153.84
Ping Zhu380.91
Fulei Nie480.91
Jun Yang580.91
Xuyang Wang692.06
Ping Dai780.91
Hao Lin815016.08
Feng-Biao Guo9628.49
Nini Rao108511.36