Name
Title | ||
|---|---|---|
The multiple common point set problem and its application to molecule binding pattern detection. |
Abstract | ||
|---|---|---|
Recognition of binding patterns common to a set of protein structures is important for recognition of function, prediction of binding, and drug design. We consider protein binding sites represented by a set of 3D points with assigned physico-chemical and geometrical properties important for protein-ligand interactions. We formulate the multiple binding site alignment problem as detection of the largest common set of such 3D points. We discuss the computational problem of multiple common point set detection and, particularly, the matching problem in K-partite-epsilon graphs, where K partitions are associated with K structures and edges are defined between epsilon-close points. We show that the K-partite-epsilon matching problem is NP-hard in the Euclidean space with dimension larger than one. Consequently, we show that the largest common point set problem between three point sets is NP-hard. On the practical side, we present a novel computational method, MultiBind, for recognition of binding patterns common to a set of protein structures. It performs a multiple alignment between protein binding sites in the absence of overall sequence, fold, or binding partner similarity. Despite the NP-hardness results, in our applications, we practically overcome the exponential number of multiple alignment combinations by applying an efficient branch-and-bound filtering procedure. We show applications of MultiBind to several biological targets. The method recognizes patterns which are responsible for binding small molecules, such as estradiol, ATP/ANP, and transition state analogues. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1089/cmb.2006.13.407 | JOURNAL OF COMPUTATIONAL BIOLOGY |
Keywords | Field | DocType |
multiple structure alignment of binding sites,consensus binding patterns,pattern matching,pattern discovery,recognition of functional sites,k-partite matching,common point set problem | Graph,Computational problem,Combinatorics,Euclidean space,Point set,Bioinformatics,Pattern detection,Pattern matching,Mathematics | Journal |
Volume | Issue | ISSN |
13.0 | 2 | 1066-5277 |
Citations | PageRank | References |
25 | 1.28 | 18 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Maxim Shatsky | 1 | 127 | 13.11 |
| Alexandra Shulman-peleg | 2 | 307 | 21.59 |
| Ruth Nussinov | 3 | 845 | 113.97 |
| Haim J Wolfson | 4 | 1837 | 495.25 |