Paper Info
Title
New evidence for involvement of the entorhinal region in schizophrenia: a combined MRI volumetric and DTI study.
Abstract
Postmortem examinations and magnetic resonance imaging (MRI) studies suggest involvement of the entorhinal cortex (EC) in schizophrenic psychoses. However, the extent and nature of the possible pathogenetical process underlying the observed alterations of this limbic key region for processing of multimodal sensory information remains unclear. Three-dimensional high-resolution MRI volumetry and evaluation of the regional diffusional anisotropy based on diffusion tensor imaging (DTI) were performed on the EC of 15 paranoid schizophrenic patients and 15 closely matched control subjects. In schizophrenic patients, EC volumes showed a slight, but not significant, decrease. However, the anisotropy values, expressed as inter-voxel coherences (COH), were found to be significantly decreased by 17.9% (right side) and 12.5% (left side), respectively, in schizophrenics. Reduction of entorhinal diffusional anisotropy can be hypothesized to be functionally related to disturbances in the perforant path, the principal efferent EC fiber tract supplying the limbic system with neuronal input from multimodal association centers. Combinations of different MRI modalities are a promising approach for the detection and characterization of subtle brain tissue alterations.
Year
DOI
Venue
2005
10.1016/j.neuroimage.2004.10.007
NeuroImage
Keywords
DocType
Volume
Volumetry,Diffusion tensor imaging,Entorhinal region,Schizophrenia
Journal
24
Issue
ISSN
Citations 
4
1053-8119
4
PageRank 
References 
Authors
0.85
2
9
Name
Order
Citations
PageRank
Peter Kalus1175.23
Johannes Slotboom2122.40
Jürgen Gallinat3389.82
Andrea Federspiel4426.28
Jan Gralla561.52
Luca Remonda641.19
Werner K Strik7161.87
Gerhard Schroth8233.75
Claus Kiefer991.37