Paper Info
Title
MitoBreak: the mitochondrial DNA breakpoints database.
Abstract
Mitochondrial DNA (mtDNA) rearrangements are key events in the development of many diseases. Investigations of mtDNA regions affected by rearrangements (i.e. breakpoints) can lead to important discoveries about rearrangement mechanisms and can offer important clues about the causes of mitochondrial diseases. Here, we present the mitochondrial DNA breakpoints database (MitoBreak; http://mitobreak.portugene.com), a free, web-accessible comprehensive list of breakpoints from three classes of somatic mtDNA rearrangements: circular deleted (deletions), circular partially duplicated (duplications) and linear mtDNAs. Currently, MitoBreak contains >1400 mtDNA rearrangements from seven species (Homo sapiens, Mus musculus, Rattus norvegicus, Macaca mulatta, Drosophila melanogaster, Caenorhabditis elegans and Podospora anserina) and their associated phenotypic information collected from nearly 400 publications. The database allows researchers to perform multiple types of data analyses through user-friendly interfaces with full or partial datasets. It also permits the download of curated data and the submission of new mtDNA rearrangements. For each reported case, MitoBreak also documents the precise breakpoint positions, junction sequences, disease or associated symptoms and links to the related publications, providing a useful resource to study the causes and consequences of mtDNA structural alterations.
Year
DOI
Venue
2014
10.1093/nar/gkt982
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
phenotype,internet
Homo sapiens,Podospora anserina,Biology,Phenotype,mtDNA control region,Caenorhabditis elegans,Mitochondrial DNA,Breakpoint,Drosophila melanogaster,Genetics,Database
Journal
Volume
Issue
ISSN
42
D1
0305-1048
Citations 
PageRank 
References 
1
0.38
5
Authors
4
Name
Order
Citations
PageRank
Joana Damas110.38
João Carneiro232.46
António Amorim311.06
Filipe Pereira411.06