Name
Title | ||
|---|---|---|
Left prefrontal cortex control of novel occurrences during recollection: a psychopharmacological study using scopolamine and event-related fMRI. |
Abstract | ||
|---|---|---|
Recollection and familiarity represent two processes involved in episodic memory retrieval. We investigated how scopolamine (an antagonist of acetylcholine muscarinic receptors) influenced brain activity during memory retrieval, using a paradigm that separated recollection and familiarity. Eighteen healthy volunteers were recruited in a randomized, placebo-controlled, double-blind design using event-related fMRI. Participants were required to perform a verbal recognition memory task within the scanner, either under placebo or scopolamine conditions. Depending on the subcondition, participants were required to make a simple recognition decision (old/new items) or base their decision on more specific information related to prior experience (target/non-target/new items). We show a drug modulation in left prefrontal and perirhinal cortex during recollection. Such an effect was specifically driven by novelty and showed an inverse correlation with accuracy performance. Additionally, we show a direct correlation between drug-related signal change in left prefrontal and perirhinal cortices. We discuss the findings in terms of acetylcholine mediation of the familiarity/novelty signal through perirhinal cortex and the control of the relative signal strength through prefrontal cortex. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1016/j.neuroimage.2006.06.044 | NeuroImage |
Keywords | Field | DocType |
fMRI,Scopolamine,Episodic memory,Recollection,Familiarity | Perirhinal cortex,Developmental psychology,Consumer neuroscience,Episodic memory,Recognition memory,Prefrontal cortex,Psychology,Cognitive psychology,Brain activity and meditation,Novelty,Recall | Journal |
Volume | Issue | ISSN |
33 | 1 | 1053-8119 |
Citations | PageRank | References |
0 | 0.34 | 1 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Marco Bozzali | 1 | 80 | 8.03 |
| S E MacPherson | 2 | 0 | 0.34 |
| R. J. Dolan | 3 | 156 | 15.39 |
| Tim Shallice | 4 | 26 | 4.09 |