Name
Abstract | ||
|---|---|---|
The purpose of this study was to evaluate the effects of longitudinal drift in scanner hardware, inter-scanner variability (bias) and scanner upgrade on asymmetries of diffusion properties using longitudinal data obtained on two scanners of the exact same model at one institution. A total of 224 normal subjects (63 females and 161 males) were included in this study. Each subject was scanned twice, at an interval of about 1year (mean interval=1.0±0.11years, range=0.6–1.3years), using two 3.0-T scanners of the exact same model. Both scanners were simultaneously upgraded during the study period (159 subjects underwent a follow-up scan before upgrade, and the remaining 65 subjects underwent a follow-up scan after upgrade). The subjects were divided into 4 groups according to the combination of scanners used. With the use of tract-based spatial statistics (TBSS), we investigated the effects of scanner drift and inter-scanner variability (bias) on asymmetries of fractional anisotropy (FA) and mean diffusivity (MD). We also investigated the effect of scanner upgrade on FA and MD asymmetries. The voxel-wise analyses revealed a number of regions with significant longitudinal changes in FA and MD asymmetries in the groups where baseline and follow-up images were obtained on different scanners. Even with scanners of the exact same model, inter-scanner variability (bias) significantly affected FA and MD asymmetries, which were relatively stable within the same scanner. Scanner upgrade had a small effect on FA and MD asymmetries. The results indicate that the use of multiple scanners increases variability of DTI asymmetry measurements, and can affect the results of cross-sectional and especially longitudinal DTI asymmetry studies. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1016/j.neuroimage.2010.09.023 | NeuroImage |
Keywords | Field | DocType |
Asymmetry,Bias,Drift,Reliability,Reproducibility,Variability | Nuclear medicine,Reproducibility,Diffusion MRI,Fractional anisotropy,Cognitive psychology,Psychology,Upgrade,Scanner,Nuclear magnetic resonance,Asymmetry | Journal |
Volume | Issue | ISSN |
54 | 2 | 1053-8119 |
Citations | PageRank | References |
3 | 0.42 | 8 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Hidemasa Takao | 1 | 9 | 2.51 |
| Naoto Hayashi | 2 | 20 | 6.38 |
| Kuni Ohtomo | 3 | 45 | 11.32 |