Paper Info
Title
The dominant morphology of fractionated atrial electrograms has greater temporal stability in persistent as compared with paroxysmal atrial fibrillation
Abstract
Background: Measurements of both the dominant frequency (DF) and the time series morphology of complex fractionated atrial electrograms (CFAE) are useful to distinguish persistent from paroxysmal atrial fibrillation (AF). In this study, an algorithm was devised to extract morphologic components according to frequency, and its usefulness for distinguishing CFAE was shown. Method: CFAE of length 16s were obtained at two sites each from the four pulmonary vein ostia (PV), and from anterior and posterior left atrial free wall (FW), in nine paroxysmal and 10 longstanding persistent AF patients. The DF was computed for each of two 8s CFAE segments in each 16s recording. Each CFAE segment was then transformed into a set of basis vectors, which represent electrogram morphology at each frequency. The dominant morphology (DM) is defined as the ensemble average of sequential signal segments, with the segment length equal to the period at the DF. The DMs of the two 8s pairs were correlated. Normalized correlation coefficients were tabulated for all data, and separately for PV and FW. The means and coefficients of variation of the DM correlation coefficients were then plotted, and a linear discriminant function was used to classify persistent versus paroxysmal AF data. For comparison with DM results, CFE-mean and interval confidence level (ICL) were also calculated for persistent versus paroxysmal AF data. Results: Mean correlation of the DM, 1st 8s versus 2nd 8s data, was 0.62+0.22 for persistent versus 0.50+0.19 for paroxysmal CFAE for all recording sites (p
Year
DOI
Venue
2013
10.1016/j.compbiomed.2013.08.027
Comp. in Bio. and Med.
Keywords
DocType
Volume
Atrial fibrillation,Dominant frequency,Dominant morphology,Fractionation,Spectral analysis
Journal
43
Issue
ISSN
Citations 
12
0010-4825
2
PageRank 
References 
Authors
1.09
0
3
Name
Order
Citations
PageRank
Edward J. Ciaccio116530.79
Angelo B. Biviano273.13
Hasan Garan3157.97