Title
Are the fractal skeletons the explanation for the narrowing of arteries due to cell trapping in a disturbed blood flow?
Abstract
We show that common circulatory diseases, such as stenoses and aneurysms, generate chaotic advection of blood particles. This phenomenon has major consequences on the way the biochemical particles behave. Chaotic advection leads to a peculiar filamentary particle distribution, which in turn creates a favorable environment for particle reactions. Furthermore, we argue that the enhanced stretching dynamics induced by chaos can lead to the activation of platelets, particles involved in the thrombus formation. In particular, we vary the size of both stenoses and aneurysms, and model them under resting and exercising conditions. We show that the filamentary particle distribution, governed by the fractal skeleton, depends on the size of the vessel wall irregularity, and investigate how it varies under resting or exercising conditions.
Year
DOI
Venue
2012
10.1016/j.compbiomed.2011.07.002
Comp. in Bio. and Med.
Keywords
DocType
Volume
Blood flow,Cardiovascular system,Chaos,Nonlinear dynamics
Journal
42
Issue
ISSN
Citations 
3
0010-4825
0
PageRank 
References 
Authors
0.34
0
5
Name
Order
Citations
PageRank
Adriane B. Schelin100.34
György Károlyi200.68
Alessandro P. S. de Moura381.90
Nuala Booth400.34
Celso Grebogi512734.41