Name
Title | ||
|---|---|---|
Simultaneous laser Doppler flowmetry and arterial spin labeling MRI for measurement of functional perfusion changes in the cortex. |
Abstract | ||
|---|---|---|
This study compares laser Doppler flowmetry (LDF) and arterial spin labeling (ASL) for the measurement of functional changes in cerebral blood flow (CBF). The two methods were applied concurrently in a paradigm of electrical whisker stimulation in the anaesthetised rat. Multi-channel LDF was used, with each channel corresponding to different fiber separation (and thus measurement depth). Continuous ASL was applied using separate imaging and labeling coils at 3 T. Careful experimental set up ensured that both techniques recorded from spatially concordant regions of the barrel cortex, where functional responses were maximal. Strong correlations were demonstrated between CBF changes measured by each LDF channel and ASL in terms of maximum response magnitude and response time-course within a 6-s-long temporal resolution imposed by ASL. Quantitatively, the measurements of the most superficial LDF channels agreed strongly with those of ASL, whereas the deeper LDF channels underestimated consistently the ASL measurement. It was thus confirmed that LDF quantifies CBF changes consistently at a superficial level, and for this case the two methods provided concordant measures of functional CBF changes, despite their essentially different physical principles and spatiotemporal characteristics. |
Year | DOI | Venue |
|---|---|---|
2007 | 10.1016/j.neuroimage.2006.11.017 | NeuroImage |
Keywords | Field | DocType |
Perfusion,Cerebral blood flow,Arterial spin labeling,Laser Doppler flowmetry,Brain,Rat | Cortex (botany),Biomedical engineering,Neuroscience,Laser Doppler velocimetry,Psychology,Site-directed spin labeling,Cognitive psychology,Barrel cortex,Cerebral blood flow,Arterial Spin Labeling MRI,Temporal resolution,Perfusion | Journal |
Volume | Issue | ISSN |
34 | 4 | 1053-8119 |
Citations | PageRank | References |
2 | 0.43 | 1 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Jiabao He | 1 | 3 | 0.78 |
| Ian M Devonshire | 2 | 16 | 1.51 |
| John E. W. Mayhew | 3 | 233 | 322.10 |
| Nikos G. Papadakis | 4 | 22 | 2.89 |