Paper Info
Title
iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence.
Abstract
We present iRefWeb, a web interface to protein interaction data consolidated from 10 public databases: BIND, BioGRID, CORUM, DIP, IntAct, HPRD, MINT, MPact, MPPI and OPHID. iRefWeb enables users to examine aggregated interactions for a protein of interest, and presents various statistical summaries of the data across databases, such as the number of organism-specific interactions, proteins and cited publications. Through links to source databases and supporting evidence, researchers may gauge the reliability of an interaction using simple criteria, such as the detection methods, the scale of the study (high- or low-throughput) or the number of cited publications. Furthermore, iRefWeb compares the information extracted from the same publication by different databases, and offers means to follow-up possible inconsistencies. We provide an overview of the consolidated protein-protein interaction landscape and show how it can be automatically cropped to aid the generation of meaningful organism-specific interactomes. iRefWeb can be accessed at: http://wodaklab.org/iRefWeb.
Year
DOI
Venue
2010
10.1093/database/baq023
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
Keywords
Field
DocType
database management systems,internet,computational biology,proteins
Data mining,Protein structure database,World Wide Web,Interactive analysis,Information retrieval,Computer science,Bioinformatics,User interface,The Internet,Data display
Journal
Volume
ISSN
Citations 
2010
1758-0463
32
PageRank 
References 
Authors
1.45
21
9
Name
Order
Citations
PageRank
Brian Turner1503.30
Sabry Razick21728.37
Andrei L. Turinsky3846.13
James Vlasblom41396.96
Edgard K Crowdy5321.45
Emerson Cho6321.45
Kyle Morrison7342.18
Ian M Donaldson81969.41
S J Wodak950295.66