Paper Info
Title
76-space analysis of grey matter diffusivity: methods and applications.
Abstract
Diffusion Weighted Imaging (DWI) and Diffusion Tensor Imaging (DTI) are widely used in the study and diagnosis of neurological diseases involving the White Matter (WM). However, many neurological and neurodegenerative diseases (e.g., Alzheimer’s disease and Creutzfeldt-Jakob disease) are generally considered to involve the Grey Matter (GM). Investigation of GM diffusivity of normal aging and pathological brains has both scientific significance and clinical applications. Most of previous research reports on quantification of GM diffusivity were based on the manually labeled Region of Interests (ROI) analysis of specific neuroanatomic regions. The well-known drawbacks of ROI analysis include inter-rater variations, irreproducible results, tediousness, and requirement of a priori definition of interested regions. In this paper, we present a new framework of automated 76-space analysis of GM diffusivity using DWI/DTI. The framework will be evaluated using clinical data, and applied for study of normal brain, Creutzfeldt-Jakob disease and Schizophrenia.
Year
DOI
Venue
2006
10.1016/j.neuroimage.2005.11.041
Medical Image Computing and Computer-Assisted Intervention
Keywords
Field
DocType
roi analysis,white matter,neurological disease,diffusion tensor imaging,gm diffusivity,grey matter diffusivity,diffusion weighted imaging,neurodegenerative disease,creutzfeldt-jakob disease,grey matter,76-space analysis,region of interest
Effective diffusion coefficient,Diffusion MRI,Grey matter,White matter,Pattern recognition,Computer science,Fractional anisotropy,Artificial intelligence,Thermal diffusivity
Journal
Volume
Issue
ISSN
8
Pt 1
1053-8119
ISBN
Citations 
PageRank 
3-540-29327-2
15
1.28
References 
Authors
15
5
Name
Order
Citations
PageRank
Tianming Liu11529.92
Geoffrey S. Young2597.58
Ling Huang3151.28
Nan-kuei Chen47813.80
Stephen T. C. Wong51081134.56