Name
Abstract | ||
|---|---|---|
Our investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among homologues, we also identify an exception in a transcarbamylase. This allows us to exemplify the function of knots in proteins and to suggest how they may have been created. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1371/journal.pcbi.0020122 | PLOS COMPUTATIONAL BIOLOGY |
Keywords | Field | DocType |
computational biology,dna fragmentation,protein data bank,data analysis,protein structure,enzyme,protein binding | Plasma protein binding,Viral Structure,Biology,Ubiquitin,Proteasome,Bioinformatics,Protein Data Bank,Hydrolase,Knot (unit),Protein structure | Journal |
Volume | Issue | ISSN |
2 | 9 | 1553-7358 |
Citations | PageRank | References |
18 | 2.49 | 2 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Peter Virnau | 1 | 180 | 19.44 |
| Leonid A. Mirny | 2 | 69 | 8.99 |
| Mehran Kardar | 3 | 41 | 5.02 |