Title
A hierarchical multi-label classification ant colony algorithm for protein function prediction
Abstract
This paper proposes a novel ant colony optimisation (ACO) algorithm tailored for the hierarchical multi-label classification problem of protein function prediction. This problem is a very active research field, given the large increase in the number of uncharacterised proteins available for analysis and the importance of determining their functions in order to improve the current biological knowledge. Since it is known that a protein can perform more than one function and many protein functional-definition schemes are organised in a hierarchical structure, the classification problem in this case is an instance of a hierarchical multi-label problem. In this type of problem, each example may belong to multiple class labels and class labels are organised in a hierarchical structure—either a tree or a directed acyclic graph structure. It presents a more complex problem than conventional flat classification, given that the classification algorithm has to take into account hierarchical relationships between class labels and be able to predict multiple class labels for the same example. The proposed ACO algorithm discovers an ordered list of hierarchical multi-label classification rules. It is evaluated on sixteen challenging bioinformatics data sets involving hundreds or thousands of class labels to be predicted and compared against state-of-the-art decision tree induction algorithms for hierarchical multi-label classification.
Year
DOI
Venue
2010
10.1007/s12293-010-0045-4
Memetic Computing
Keywords
Field
DocType
hierarchical multi-label classification · ant colony optimisation · protein function prediction,computer programming,directed acyclic graph,ant colony algorithm,protein function prediction
Ant colony optimization algorithms,Decision tree,Data mining,Data set,Directed acyclic graph,Multi-label classification,Artificial intelligence,Ant colony,Protein function prediction,Mathematics,Computer programming,Machine learning
Journal
Volume
Issue
ISSN
2
3
1865-9292
Citations 
PageRank 
References 
28
0.80
28
Authors
3
Name
Order
Citations
PageRank
Fernando E. B. Otero130621.29
J A Foster288481.48
Colin G. Johnson3933115.57