Paper Info
Title
Functional MRI reveals frequency-dependent responses during deep brain stimulation at the subthalamic nucleus or internal globus pallidus.
Abstract
Deep brain stimulation (DBS) represents a widely used therapeutic tool for the symptomatic treatment of movement disorders, most commonly Parkinson's disease (PD). High frequency stimulation at both the subthalamic nucleus (STN) and internal globus pallidus (GPi) has been used with great success for the symptomatic treatment of PD, although the therapeutic mechanisms of action remain elusive. To better understand how DBS at these target sites modulates neural circuitry, the present study used functional blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to map global brain responses to DBS at the STN and GPi of the rat. Robust activation centered in the ipsilateral motor cortex was observed during high frequency stimulation at either target site, with peak responses observed at a stimulation frequency of 100Hz. Of note, frequency tuning curves were generated, demonstrating that cortical activation was maximal at clinically-relevant stimulation frequencies. Divergent responses to stimulation were noted in the contralateral hemisphere, with strong cortical and striatal negative BOLD signal during stimulation of the GPi, but not STN. The frequency-dependence of the observed motor cortex activation at both targets suggests a relationship with the therapeutic effects of STN and GPi DBS, with both DBS targets being functionally connected with motor cortex at therapeutic stimulation frequencies.
Year
DOI
Venue
2014
10.1016/j.neuroimage.2013.08.026
NeuroImage
Keywords
Field
DocType
Deep brain stimulation,fMRI,Subthalamic nucleus,Internal globus pallidus,Functional connectivity,Rat
Deep brain stimulation,Globus pallidus,Neuroscience,Movement disorders,Functional magnetic resonance imaging,Psychology,Motor cortex,Biological neural network,Subthalamic nucleus,Stimulation
Journal
Volume
ISSN
Citations 
84
1053-8119
8
PageRank 
References 
Authors
0.87
4
5
Name
Order
Citations
PageRank
Hsin-Yi Lai1588.37
John R Younce280.87
Daniel L. Albaugh3162.05
Yu-Chieh Jill Kao4121.31
Yen-Yu I. Shih5355.06