Name
Abstract | ||
|---|---|---|
A patch-clamp (PC) microchip with integrated air-bubble actuators (AB actuators) for cell positioning is demonstrated, showing the promise for an automated PC microsystem. AB actuators are pneumatic actuators. The air pressure is generated by PDMS membrane mechanical deformation. By integrating with microfluidic channels and PC electrodes, AB actuators can potentially help avoid drawbacks of random cell selection or positioning for a PC microchip, paving the way for an automated PC microsystem. In this effort, the lateral electrode-pipette, located opposite to the outlet of an AB actuator, is designed for trapping a cell. The positioning and capturing of 3T3 cells were demonstrated successfully. Measurements found that the electrode impedance is 1MΩ the seal resistance is 5MΩ with a captured cell. Optimization of the size and shape of the pipette is underway to enhance the seal resistance. |
Year | DOI | Venue |
|---|---|---|
2009 | 10.1109/NEMS.2009.5068577 | NEMS |
Keywords | Field | DocType |
seal resistance,cell positioning,automated pc microsystem,integrated actuators,ab actuator,pc electrode,ab actuators,random cell selection,pneumatic actuators,pc microchip,patch-clamp device,integrated air-bubble actuators,deformation,patch clamp,electrodes,resistance,microfluidics,actuators,media | Microsystem,Composite material,Pipette,Pneumatic actuator,Microfluidics,Patch clamp,Materials science,Microfluidic channel,Optoelectronics,Electrode,Actuator | Conference |
ISSN | Citations | PageRank |
2474-3747 | 0 | 0.34 |
References | Authors | |
0 | 5 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Zhongcheng Gong | 1 | 0 | 1.35 |
| Krithika Nagarajan | 2 | 0 | 0.34 |
| Siva Penmetsa | 3 | 0 | 1.01 |
| David Mills | 4 | 0 | 1.01 |
| Long Que | 5 | 2 | 1.80 |