Title
When NMDA Receptor Conductances Increase Inter-spike Interval Variability
Abstract
We analyze extensively the temporal properties of the train of spikes emitted by a simple model neuron as a function of the statistics of the synaptic input. In particular we focus on the asynchronous case, in which the synaptic inputs are random and uncorrelated. We show that the NMDA component acts as a non-stationary input that varies on longer time scales than the inter-spike intervals. In the subthreshold regime, this can increase dramatically the coefficient of variability (bringing it beyond one). The analysis provides also simple guidelines for searching parameters that maximize irregularity.
Year
DOI
Venue
2002
10.1007/3-540-46084-5_39
ICANN
Keywords
Field
DocType
inter-spike interval,non-stationary input,subthreshold regime,longer time scale,synaptic input,nmda receptor conductances,asynchronous case,simple model neuron,temporal property,nmda component act,inter-spike interval variability,simple guideline,nmda receptor
Asynchronous communication,Synapse,Pattern recognition,Biological system,Computer science,NMDA receptor,Uncorrelated,Artificial intelligence,Subthreshold conduction,Artificial neural network,Spike potential,Statistical analysis
Conference
Volume
ISSN
ISBN
2415
0302-9743
3-540-44074-7
Citations 
PageRank 
References 
0
0.34
2
Authors
5
Name
Order
Citations
PageRank
Giancarlo La Camera1385.05
Stefano Fusi266990.97
Walter Senn331627.52
Alexander Rauch441.29
Hans-rudolf Lüscher512711.09