Name
Abstract | ||
|---|---|---|
This work examines the influence of changes in baseline activity on the intrinsic functional connectivity fMRI (fc-fMRI) in humans. Baseline brain activity was altered by inducing anesthesia (sevoflurane end-tidal concentration 1%) in human volunteers and fc-fMRI maps between the pre-anesthetized and anesthetized conditions were compared across different brain networks. We particularly focused on low-level sensory areas (primary somatosensory, visual, and auditory cortices), the thalamus, and pain (insula), memory (hippocampus) circuits, and the default mode network (DMN), the latter three to examine higher-order brain regions. The results indicate that, while fc-fMRI patterns did not significantly differ (p<0.005; 20-voxel cluster threshold) in sensory cortex and in the DMN between the pre- and anesthetized conditions, fc-fMRI in high-order cognitive regions (i.e. memory and pain circuits) was significantly altered by anesthesia. These findings provide further evidence that fc-fMRI reflects intrinsic brain properties, while also demonstrating that 0.5 MAC sevoflurane anesthesia preferentially modulates higher-order connections. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.1016/j.neuroimage.2009.07.028 | NeuroImage |
Keywords | Field | DocType |
Anesthesia,Functional connectivity,Functional magnetic resonance imaging,Low-sensory areas,Thalamus,Insula,Hippocampus,Default mode network | Insula,Brain mapping,Developmental psychology,Default mode network,Sensory cortex,Neuroscience,Functional magnetic resonance imaging,Psychology,Brain activity and meditation,Somatosensory system,Hippocampus | Journal |
Volume | Issue | ISSN |
49 | 1 | 1053-8119 |
Citations | PageRank | References |
30 | 2.59 | 9 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Roberto Martuzzi | 1 | 41 | 4.10 |
| Ramachandran Ramani | 2 | 44 | 3.80 |
| Maolin Qiu | 3 | 107 | 9.85 |
| Nallakkandi Rajeevan | 4 | 39 | 3.78 |
| R Todd Constable | 5 | 848 | 77.34 |