Paper Info
Title
The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases.
Abstract
Prion diseases reflect conformational conversion of benign isoforms of prion protein (PrPC) to malignant PrPSc isoforms. Networks perturbed by PrPSc accumulation and their ties to pathological events are poorly understood. Time-course transcriptomic and phenotypic data in animal models are critical for understanding prion-perturbed networks in systems biology studies. Here, we present the Prion Disease Database (PDDB), the most comprehensive data resource on mouse prion diseases to date. The PDDB contains: (i) time-course mRNA measurements spanning the interval from prion inoculation through appearance of clinical signs in eight mouse strain-prion strain combinations and (ii) histoblots showing temporal PrPSc accumulation patterns in brains from each mouse-prion combination. To facilitate prion research, the PDDB also provides a suite of analytical tools for reconstructing dynamic networks via integration of temporal mRNA and interaction data and for analyzing these networks to generate hypotheses. Database URL: http://prion.systemsbiology.net
Year
DOI
Venue
2009
10.1093/database/bap011
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
Keywords
Field
DocType
system biology
Data mining,Disease,Gene isoform,Phenotype,Biology,Transcriptome,Systems biology,Bioinformatics,Database
Journal
Volume
Issue
ISSN
2009
0
1758-0463
Citations 
PageRank 
References 
0
0.34
10
Authors
11
Name
Order
Citations
PageRank
Nils Gehlenborg136336.48
Daehee Hwang26812.13
Inyoul Y Lee3121.84
Hyuntae Yoo430.97
David Baxter500.34
Brianne Petritis600.34
Rose Pitstick700.34
Bruz Marzolf8222.94
Stephen J Dearmond900.34
George A Carlson1000.34
Leroy Hood1116545.56