Name
Abstract | ||
|---|---|---|
The advent of the so-called cDNA microarrays has offered the first possibility to obtain a global understanding of biological processes in living organisms by simultaneous readouts of tens of thousands of genes. Initial experiments suggest that genes with similar function have similar expression patterns in microarray experiments. Until now, most approaches to computational analysis of gene expressions have used unsupervised learning. Although in some cases unsupervised methods may be sufficient, the complexity of the biological processes is so high that it is unlikely that purely syntactical analyses are capable of fully exploiting the richness of the microarray data. In addition, it seems natural to re-use the existing biological (background) knowledge. In this paper, we present some elements of a methodology for knowledge discovery from microarray experiments. Two source of bio-medical knowledge are used: Ashburner's gene ontology and our own literature-derived network of gene-gene relations obtained by analysing Medline citation records. Predictive models can be induced and their classification quality validated through the ROC/AUC analysis and applied to provide hypotheses regarding the function of unclassified genes. The methodology has been so far tested on publicly available gene expression data and its results evaluated by molecular biologists and medical researchers. |
Year | DOI | Venue |
|---|---|---|
2000 | 10.1007/3-540-45372-5_53 | PKDD |
Keywords | Field | DocType |
biological process,towards knowledge discovery,cdna microarray gene expression,knowledge discovery,unclassified gene,gene ontology,microarray experiment,bio-medical knowledge,gene expression,auc analysis,microarray data,available gene expression data,supervised learning,prediction model | Data mining,Microarray,Computer science,Knowledge-based systems,Microarray analysis techniques,Unsupervised learning,Knowledge extraction,Artificial intelligence,Gene chip analysis,Microarray databases,Machine learning,Knowledge acquisition | Conference |
Volume | ISSN | ISBN |
1910 | 0302-9743 | 3-540-41066-X |
Citations | PageRank | References |
3 | 0.44 | 3 |
Authors | ||
7 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Henryk Jan Komorowski | 1 | 542 | 146.83 |
| Torgeir R. Hvidsten | 2 | 180 | 14.52 |
| Tor-Kristian Jenssen | 3 | 120 | 22.05 |
| Dyre Tjeldvoll | 4 | 3 | 0.44 |
| Eivind Hovig | 5 | 215 | 21.79 |
| Arne K. Sanvik | 6 | 3 | 0.44 |
| Astrid Lægreid | 7 | 195 | 19.82 |