Paper Info
Title
Kinetic analyses of [123I]IBZM SPECT for quantification of striatal dopamine D2 receptor binding: A critical evaluation of the single-scan approach.
Abstract
Background: Dopamine-D2 receptor imaging with single-photon emission computed tomography (SPECT) and [(123)I]IBZM is of great interest for basic and applied neurosciences. However, the use of kinetic analyses for quantification of dynamic [(123)I]IBZM SPECT and the validity of the commonly employed single-scan pseudo-equilibrium analysis (PsEA) have not been appropriately investigated. The present study addresses these shortcomings. Methods: Ten movement disorder patients underwent dynamic SPECT (142 min) after single-bolus [(123)I]IBZM injection. Kinetic analyses comprise: simplified reference tissue model (SRTM), multi-linear reference tissue model (MRTM), their two-parameter versions (SRTM2/MRTM2) and non-invasive graphical analysis (NIGA). Simplified single-scan analyses were performed at peak time of specific binding (peak-equilibrium analysis, PEA) and during pseudo-equilibrium (PsEA). Results: SRTM and MRTM are compromised by the high noise level of dynamic SPECT. SRTM2 and MRTM2 yielded reliable binding potential estimates that agreed excellently (mean difference = -0.1 +/- 1.0%, R(2)>0.99). Concordance between SRTM/MRTM and SRTM2/MRTM2 was high in cases in which SRTM/MRTM provided reliable results (SRTM2 or MRTM2 vs. SRTM: 3.7 +/- 5.0%, R(2) = 0.88). NIGA was affected by a negative bias (-9.1 +/- 63%, R(2) = 0.75: MRTM2 as reference) or high variability (-1.2 +/- 7.4%, R(2) = 0.71) for analyses without and with inclusion of the k(2)'-term, respectively. PsEA showed a positive bias and low correlation in comparison with SRTM2/MRTM2 (7.6 +/- 10.8%, R(2) = 0.59), which was considerably improved for PEA (-2.7 +/- 7.6%, R(2) = 0.72). MRTM2 provided parametric images with minimal bias Suited for voxel-wise statistical analyses. Conclusions: MRTM2 and SRTM2 can be reliably applied to dynamic [(123)I]IBZM SPECT. PEA is a suitable method for clinical routine, while our results discourage the use of PsEA (current clinical standard). (C) 2008 Elsevier Inc. All rights reserved.
Year
DOI
Venue
2008
10.1016/j.neuroimage.2008.05.023
NeuroImage
Keywords
Field
DocType
SPECT,Dopamine-D2 receptor,[123I]IBZM,Tracer kinetic analysis
Nuclear medicine,Emission computed tomography,Graphical analysis,Noise level,Psychology,Tissue Model,Binding potential,Low correlation
Journal
Volume
Issue
ISSN
42
2
1053-8119
Citations 
PageRank 
References 
0
0.34
0
Authors
9
Name
Order
Citations
PageRank
Philipp T. Meyer1102.32
Bernhard Sattler200.68
Oliver H. Winz300.68
Rico Fundke400.34
Christian Oehlwein500.34
Kai Kendziorra600.34
Swen Hesse722.83
Wolfgang M. Schaefer801.35
Osama Sabri9137.33