Paper Info
Title
Shunting inhibition controls the gain modulation mediated by asynchronous neurotransmitter release in early development.
Abstract
The sensitivity of a neuron to its input can be modulated in several ways. Changes in the slope of the neuronal input-output curve depend on factors such as shunting inhibition, background noise, frequency-dependent synaptic excitation, and balanced excitation and inhibition. However, in early development GABAergic interneurons are excitatory and other mechanisms such as asynchronous transmitter release might contribute to regulating neuronal sensitivity. We modeled both phasic and asynchronous synaptic transmission in early development to study the impact of activity-dependent noise and short-term plasticity on the synaptic gain. Asynchronous release decreased or increased the gain depending on the membrane conductance. In the high shunt regime, excitatory input due to asynchronous release was divisive, whereas in the low shunt regime it had a nearly multiplicative effect on the firing rate. In addition, sensitivity to correlated inputs was influenced by shunting and asynchronous release in opposite ways. Thus, asynchronous release can regulate the information flow at synapses and its impact can be flexibly modulated by the membrane conductance.
Year
DOI
Venue
2010
10.1371/journal.pcbi.1000973
PLOS COMPUTATIONAL BIOLOGY
Keywords
Field
DocType
information flow,input output,hippocampus,neuronal plasticity,synaptic transmission
Asynchronous communication,Synapse,Shunting,Neuroscience,Anatomy,Neurotransmission,Biology,Excitatory postsynaptic potential,Shunting inhibition,Bioinformatics,Neuron,Neurotransmitter
Journal
Volume
Issue
ISSN
6
11
1553-7358
Citations 
PageRank 
References 
6
0.56
1
Authors
3
Name
Order
Citations
PageRank
Vladislav Volman111212.54
Herbert Levine28212.58
Terrence J. Sejnowski382782135.10