Paper Info
Title
Numerical investigation and identification of susceptible sites of atherosclerotic lesion formation in a complete coronary artery bypass model.
Abstract
As hemodynamics is widely believed to correlate with anastomotic stenosis in coronary bypass surgery, this paper investigates the flow characteristics and distributions of the hemodynamic parameters (HPs) in a coronary bypass model (which includes both proximal and distal anastomoses), under physiological flow conditions. Disturbed flows (flow separation/reattachment, vertical and secondary flows) as well as regions of high oscillatory shear index (OSI) with low wall shear stress (WSS), i.e., high-OSI-and-low-WSS and low-OSI-and-high-WSS were found in the proximal and distal anastomoses, especially at the toe and heel regions of distal anastomosis, which indicate highly suspected sites for the onset of the atherosclerotic lesions. The flow patterns found in the graft and distal anastomoses of our model at deceleration phases are different from those of the isolated distal anastomosis model. In addition, a huge significant difference in segmental averages of HPs was found between the distal and proximal anastomoses. These findings further suggest that intimal hyperplasia would be more prone to form in the distal anastomosis than in the proximal anastomosis, particularly along the suture line at the toe and heel of distal anastomosis.
Year
DOI
Venue
2008
10.1007/s11517-008-0320-4
Med. Biol. Engineering and Computing
Keywords
Field
DocType
numerical simulationpulsatile flow � complete anastomosiscoronary artery bypass � hemodynamic parameters,wall shear stress,indexation
Hemodynamics,Artery,Anatomy,Pulsatile flow,Anastomosis,Internal medicine,Bypass surgery,Cardiology,Intimal hyperplasia,Stenosis,Heel,Medicine
Journal
Volume
Issue
ISSN
46
7
1741-0444
Citations 
PageRank 
References 
4
0.95
0
Authors
5
Name
Order
Citations
PageRank
Junmei Zhang1259.11
Leok Poh Chua241.29
Dhanjoo N Ghista310211.91
Simon Yu4143.53
Yong Seng Tan540.95