Name
Title | ||
|---|---|---|
Interpreting optical mapping recordings in the ischemic heart: a combined experimental and computational investigation |
Abstract | ||
|---|---|---|
The occlusion of a coronary artery results in myocardial ischemia, significantly disturbing the heart's normal electrical behavior, with potentially lethal consequences, such as sustained arrhythmias. Biologists attempt to shed light on underlying mechanisms with optical voltage mapping, a widely used technique for non-contact visualization of surface electrical activity. However, this method suffers from signal distortion due to fluorescent photon scattering within the biological tissue. The distortion effect may be more pronounced during ischemia, when a gradient of electrophysiological properties exists at the surface of the heart due to diffusion with the surrounding environment. In this paper, a combined experimental and computer simulation investigation into how photon scattering, in the presence of ischemia-induced spatial heterogeneities, distorts optical mapping recordings is performed. Dual excitation wavelength optical mapping experiments are conducted in rabbit hearts. In order to interpret experimental results a computer simulation study is performed using a 3D model of ischemic rabbit cardiac tissue combined with a model of photon diffusion to simulate optical mapping recordings. Results show that the presence of a border zone, in combination with fluorescent photon scattering, distorts the optical signal. Furthermore, changes in the illumination wavelength can alter the relative contribution of the border zone to the emitted signal. The techniques developed in this study may help with interpretation of optical mapping data in electrophysiological investigations of myocardial ischemia. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1007/978-3-642-21028-0_3 | FIMH |
Keywords | Field | DocType |
fluorescent photon scattering,myocardial ischemia,optical mapping data,photon diffusion,border zone,photon scattering,optical mapping recording,computational investigation,optical signal,excitation wavelength optical mapping,ischemic heart,optical voltage mapping,spatial heterogeneity,computer simulation,optical mapping | Biomedical engineering,Photon,Photon diffusion,Optical mapping,Computer science,Ischemia,Scattering,Distortion,Wavelength,Electrophysiology,Distributed computing | Conference |
Volume | ISSN | Citations |
6666 | 0302-9743 | 1 |
PageRank | References | Authors |
0.44 | 1 | 7 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Sara Dutta | 1 | 1 | 0.78 |
| Martin J. Bishop | 2 | 39 | 12.93 |
| Pras Pathmanathan | 3 | 111 | 11.77 |
| Peter Lee | 4 | 1 | 0.44 |
| Peter Kohl | 5 | 18 | 4.74 |
| T. Alexander Quinn | 6 | 1 | 0.78 |
| Blanca Rodriguez | 7 | 88 | 16.85 |