Title
The astrocyte as a gatekeeper of synaptic information transfer.
Abstract
We present a simple biophysical model for the coupling between synaptic transmission and the local calcium concentration on an enveloping astrocytic domain. This interaction enables the astrocyte to modulate the information flow from presynaptic to postsynaptic cells in a manner dependent on previous activity at this and other nearby synapses. Our model suggests a novel, testable hypothesis for the spike timing statistics measured for rapidly firing cells in culture experiments.
Year
DOI
Venue
2007
10.1162/neco.2007.19.2.303
Neural Computation
Keywords
Field
DocType
synaptic transmission,spike timing statistic,information flow,simple biophysical model,testable hypothesis,synaptic information transfer,nearby synapsis,culture experiment,previous activity,local calcium concentration,enveloping astrocytic domain,information transfer
Astrocyte,Neuroscience,Synapse,Neurotransmission,Information transfer,Calcium,Postsynaptic potential,Models of neural computation,Mathematics
Journal
Volume
Issue
ISSN
19
2
0899-7667
Citations 
PageRank 
References 
31
2.89
1
Authors
3
Name
Order
Citations
PageRank
Vladislav Volman111212.54
Eshel Ben-Jacob217025.37
Herbert Levine38212.58