Name
Title | ||
|---|---|---|
Immunoinformatic discovery of potential cross-reactive T cell epitopes in the measles genome |
Abstract | ||
|---|---|---|
T cells are key mediators of inflammatory processes that can be activated by pathogens and vaccines. Some vaccine antigens may encode T cell epitopes that can cross-react with either human or human microbiome epitopes, causing deviation of the T cell response, leading to beneficial or, possibly, detrimental effects. An immune response shift attributed to cross-reactive T memory cells is known as heterologous immunity. Identification of T cell epitopes contained in pathogens and their vaccines and comparison of these epitopes against human and microbial genomic datasets are important steps to ensure that adaptive immune responses elicited by a vaccine are both pathogen-specific and protective, but not cross-reactive against host or host-associated epitopes. Here, we use immunoinformatic methods to identify putative HLA A2-restricted measles vaccine epitopes that are cross-conserved with autologous proteins and with commensal microbiota. 45% and 63% of putative epitopes identified within the measles genome share significant homology to the human genome and a subset of genomes of the human microbiome, respectively. This important new information suggests there is significant potential for T cell cross-reactivity that will require experimental confirmation. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1145/2147805.2147906 | BCB |
Keywords | Field | DocType |
host-associated epitopes,human microbiome,putative epitopes,cell epitopes,measles genome,human genome,a2-restricted measles vaccine epitopes,cell cross-reactivity,human microbiome epitopes,potential cross-reactive,memory cell,cell response,immunoinformatic discovery,adaptive immunity,informatics,genome,immunology,immune response | Genome,Epitope,Biology,Antigen,Acquired immune system,Immunity,Immune system,Human leukocyte antigen,Genetics,Virology,T cell | Conference |
Citations | PageRank | References |
0 | 0.34 | 0 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Lenny Moise | 1 | 6 | 0.76 |
| Matthew Ardito | 2 | 0 | 1.35 |
| William Martin | 3 | 0 | 1.69 |
| Eric Gustafson | 4 | 17 | 4.15 |
| Alan Rothman | 5 | 0 | 0.34 |
| Anne S. De Groot | 6 | 18 | 2.89 |