Paper Info
Title
System dynamics metamodels supporting the development of computational models of the human innate immune system
Abstract
The human body is protected against pathogenic invasions by a complex system of cells, tissues and organs which form the Human Immune System (HIS). Understanding how the HIS works is therefore essential to obtain new insights into its nature and to deal effectively with diseases. Mathematical and computational modeling can be used for this purpose. Unfortunately, these complex mathematical models are very difficult to develop, understand and use by a more general and multidisciplinary team. This paper presents a System Dynamics Metamodeling tool, called JynaCore API, that supports the development of complex models using System Dynamics in a more abstract level. To demonstrate the power and usefulness of the proposed System Dynamics Metamodeling tool, in this work we present the development of a complex two-dimensional tissue model that simulates the dynamics of the immune response.
Year
DOI
Venue
2012
10.1007/978-3-642-31125-3_53
ICCSA (1)
Keywords
Field
DocType
abstract level,system dynamics,complex system,system dynamic,complex mathematical model,computational model,jynacore api,complex model,proposed system dynamics metamodeling,human immune system,human innate immune system,system dynamics metamodeling tool,complex two-dimensional tissue model
Mathematical optimization,Multidisciplinary approach,Software engineering,Simulation,Computer science,Acquired immune system,Innate immune system,Computational model,System dynamics,Mathematical model,Metamodeling
Conference
Volume
ISSN
Citations 
7333
0302-9743
0
PageRank 
References 
Authors
0.34
2
7
Name
Order
Citations
PageRank
Igor Knop100.34
Alexandre Bittencourt Pigozzo2225.03
Barbara Quintela300.34
Gilson Costa Macedo4223.56
Ciro Barbosa500.34
weber dos santos r619944.90
Marcelo Lobosco79524.89