Paper Info
Title
The comparative RNA web (CRW) site: an online database of comparative sequence and structure information for ribosomal, intron, and other RNAs.
Abstract
Comparative analysis of RNA sequences is the basis for the detailed and accurate predictions of RNA structure and the determination of phylogenetic relationships for organisms that span the entire phylogenetic tree. Underlying these accomplishments are very large, well-organized, and processed collections of RNA sequences. This data, starting with the sequences organized into a database management system and aligned to reveal their higher-order structure, and patterns of conservation and variation for organisms that span the phylogenetic tree, has been collected and analyzed. This type of information can be fundamental for and have an influence on the study of phylogenetic relationships, RNA structure, and the melding of these two fields.We have prepared a large web site that disseminates our comparative sequence and structure models and data. The four major types of comparative information and systems available for the three ribosomal RNAs (5S, 16S, and 23S rRNA), transfer RNA (tRNA), and two of the catalytic intron RNAs (group I and group II) are: (1) Current Comparative Structure Models; (2) Nucleotide Frequency and Conservation Information; (3) Sequence and Structure Data; and (4) Data Access Systems.This online RNA sequence and structure information, the result of extensive analysis, interpretation, data collection, and computer program and web development, is accessible at our Comparative RNA Web (CRW) Site http://www.rna.icmb.utexas.edu. In the future, more data and information will be added to these existing categories, new categories will be developed, and additional RNAs will be studied and presented at the CRW Site.
Year
DOI
Venue
2002
10.1186/1471-2105-3-2
BMC Bioinformatics
Keywords
Field
DocType
ribosomal rna,database management system,rna structure,data access,comparative analysis,bioinformatics,biomedical research,higher order,phylogenetic tree,microarrays,web development,structured data,data collection,algorithms,nucleotides
RNA,Phylogenetic tree,23S ribosomal RNA,Nucleic acid structure,Biology,Ribosomal RNA,Transfer RNA,Intron,Bioinformatics,Genetics,DNA microarray
Journal
Volume
Issue
ISSN
3
1
1471-2105
Citations 
PageRank 
References 
141
14.39
15
Authors
14
Search Limit
100141
Name
Order
Citations
PageRank
Jamie J. Cannone119918.89
Sankar Subramanian224022.09
Murray N Schnare315417.98
James R. Collett414715.31
Lisa M D'Souza514714.97
Yushi Du614714.97
Brian Feng714714.97
Nan Lin814714.97
Lakshmi V Madabusi914714.97
Kirsten M Müller1014714.97
Nupur Pande1114714.97
Zhidi Shang1215115.83
Nan Yu1314714.97
Robin R Gutell1417921.31