Title
Functional magnetic resonance inverse imaging of human visuomotor systems using eigenspace linearly constrained minimum amplitude (eLCMA) beamformer.
Abstract
Recently proposed dynamic magnetic resonance (MR) inverse imaging (InI) is a novel parallel imaging reconstruction technique capable of improving the temporal resolution of blood–oxygen level-dependent (BOLD) contrast functional MRI (fMRI) to the order of milliseconds at the cost of moderate spatial resolution. Volumetric InI reconstructs spatial information from projection data by solving ill-posed inverse problems using simultaneous acquisitions from a RF coil array. Previously a spatial filtering technique based on linearly constrained minimum variance (LCMV) beamformer was suggested to localize the hemodynamic changes of dynamic InI data with improved spatial resolution and sensitivity. Here we report an advancement of the spatial filtering method, which combines the eigenspace projection of the measured data and the L1-norm minimization of the spatial filters' output noise amplitude, to further improve the detection power of BOLD contrast fMRI data. Using numerical simulation and in vivo data, we demonstrate that this eigenspace linearly constrained minimum amplitude (eLCMA) beamformer can reconstruct spatiotemporal hemodynamic signals with high statistical significance values and high spatial resolution in event-related two-choice reaction time visuomotor experiments.
Year
DOI
Venue
2011
10.1016/j.neuroimage.2010.11.072
NeuroImage
Keywords
Field
DocType
Event related,fMRI,InI,Visual,Motor,MRI,Neuroimaging,L1 norm minimization,L2 norm minimization,Eigenspace projection,Beamformer,Spatial filter,LCMV,Maximized SNR,dSPM,Inverse solution,MEG,Rapid imaging
Spatial analysis,Minimum-variance unbiased estimator,Cognitive psychology,Inverse problem,Artificial intelligence,Amplitude,Temporal resolution,Spatial filter,Computer vision,Algorithm,Radiofrequency coil,Image resolution,Mathematics
Journal
Volume
Issue
ISSN
55
1
1053-8119
Citations 
PageRank 
References 
5
0.52
10
Authors
8
Name
Order
Citations
PageRank
Shr-Tai Liou150.52
Thomas Witzel237428.70
Aapo Nummenmaa325619.18
Wei-Tang Chang4727.68
Kevin Wen-Kai Tsai5494.60
Wen-Jui Kuo616320.42
Hsiao-Wen Chung751.19
Fa-Hsuan Lin824624.33