Paper Info
Title
Human brain atlas for automated region of interest selection in quantitative susceptibility mapping: Application to determine iron content in deep gray matter structures.
Abstract
The purpose of this paper is to extend the single-subject Eve atlas from Johns Hopkins University, which currently contains diffusion tensor and T1-weighted anatomical maps, by including contrast based on quantitative susceptibility mapping. The new atlas combines a “deep gray matter parcellation map” (DGMPM) derived from a single-subject quantitative susceptibility map with the previously established “white matter parcellation map” (WMPM) from the same subject's T1-weighted and diffusion tensor imaging data into an MNI coordinate map named the “Everything Parcellation Map in Eve Space,” also known as the “EvePM.” It allows automated segmentation of gray matter and white matter structures. Quantitative susceptibility maps from five healthy male volunteers (30 to 33years of age) were coregistered to the Eve Atlas with AIR and Large Deformation Diffeomorphic Metric Mapping (LDDMM), and the transformation matrices were applied to the EvePM to produce automated parcellation in subject space. Parcellation accuracy was measured with a kappa analysis for the left and right structures of six deep gray matter regions. For multi-orientation QSM images, the Kappa statistic was 0.85 between automated and manual segmentation, with the inter-rater reproducibility Kappa being 0.89 for the human raters, suggesting “almost perfect” agreement between all segmentation methods. Segmentation seemed slightly more difficult for human raters on single-orientation QSM images, with the Kappa statistic being 0.88 between automated and manual segmentation, and 0.85 and 0.86 between human raters. Overall, this atlas provides a time-efficient tool for automated coregistration and segmentation of quantitative susceptibility data to analyze many regions of interest. These data were used to establish a baseline for normal magnetic susceptibility measurements for over 60 brain structures of 30- to 33-year-old males. Correlating the average susceptibility with age-based iron concentrations in gray matter structures measured by Hallgren and Sourander (1958) allowed interpolation of the average iron concentration of several deep gray matter regions delineated in the EvePM.
Year
DOI
Venue
2013
10.1016/j.neuroimage.2013.05.127
NeuroImage
Keywords
Field
DocType
AIR,Amg,CC,CCb,CCg,CCs,CN,CSF,COSMOS,CX,DGMPM,DN,ETAAS,EvePM,EC,GM,GP,GRE,Hip,IC,INAA,LDDMM,LSQR,LVL,MEDI,MRI,PT,QSM,Put,RN,ROI,RSO,SHARP,SN,SS,TH,Th,TKD,TR,WKD,WM,WMPM
Nuclear medicine,Diffusion MRI,White matter,Quantitative susceptibility mapping,Cognitive psychology,Cohen's kappa,Artificial intelligence,Kappa,Pattern recognition,Segmentation,Psychology,Large deformation diffeomorphic metric mapping,Region of interest
Journal
Volume
ISSN
Citations 
82
1053-8119
17
PageRank 
References 
Authors
0.72
23
7
Name
Order
Citations
PageRank
Issel Anne L Lim1723.62
Andreia Faria22139.18
Xu Li3817.28
Johnny T. C. Hsu4201.09
Raag D. Airan5171.39
Susumu Mori664543.22
Peter van Zijl7109073.41