Paper Info
Title
A Simple Model For Interaction Of Voltage And Calcium Dynamics In Virtual Ventricular Tissue
Abstract
A simple two-variable model is used to replace the formulation of calcium dynamics in the Luo-Rudy ventricular cell model. Virtual ventricular cell and tissue are developed and validated to reproduce restitution properties and calcium-dependent voltage patterns present in the original model. Basic interactions between the membrane potential and Ca2+ dynamics in the virtual cell and a strand of the virtual tissue are studied. Intracellular calcium waves can be linked to both action potentials (APs) and delayed afterdepolarizations (DADs). An intracellular calcium wave propagating from the cell interior can induce an AP upon reaching the cell membrane. The voltage and the intracellular Ca2+ patterns within the same cell can be highly desynchronized. In a one-dimensional strand of the virtual tissue calcium motion is driven by the AP propagation. However, calcium release can be induced upon certain conditions (e.g. Na+ overload of the cells), which results in DADs propagating in the wake of AP. Such propagating DADs can reach the excitation threshold, generating a pair of extrasystolic APs. Collision of a propagating AP with a site of elevated intracellular Ca2+ concentration does not affect the propagation under the normal conditions. Under Na+ overload local elevation of the intracellular Ca2+ leads to generation of an extrasystolic AP, which destroys the original propagating AP.
Year
DOI
Venue
2003
10.1142/S0218127403008776
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
Keywords
DocType
Volume
calcium dynamics, Luo-Rudy model
Journal
13
Issue
ISSN
Citations 
12
0218-1274
0
PageRank 
References 
Authors
0.34
1
2
Name
Order
Citations
PageRank
Oleg V. Aslanidi12710.11
Arun V. Holden25220.71