Paper Info
Title
An intracellular Ca2+ subsystem as a biologically plausible source of intrinsic conditional bistability in a network model of working memory.
Abstract
We have developed a firing rate network model for working memory that combines Mexican-hat-like synaptic coupling with intrinsic or cellular dynamics that are conditionally bistable. While our approach is in the spirit of Camperi and Wang (1998) we include a specific and plausible mechanism for the cellular bistability. Modulatory neurotransmitters are known to activate second messenger signaling systems, and our model includes an intracellular Ca2+ handling subsystem whose dynamics depend upon the level of the second messenger inositol 1,4,5 trisphosphate (IP3). This Ca2+ subsystem endows individual units with conditional intrinsic bistability for a range of IP3. The full “hybrid” network sustains IP3-dependent persistent (“bump”) activity in response to a brief transient stimulus. The bump response in our hybrid model, like that of Camperi-Wang, is resistant to noise – its position does not drift with time.
Year
DOI
Venue
2006
10.1007/s10827-006-4791-8
Journal of Computational Neuroscience
Keywords
Field
DocType
persistent activity,working memory,computational model,calcium signaling,inositol 1,4,5 trisphosphate,neuromodulators
Bistability,Coupling,Biological system,Control theory,Working memory,Intracellular,Artificial intelligence,Stimulus (physiology),Calcium signaling,Second messenger system,Network model,Mathematics
Journal
Volume
Issue
ISSN
20
1
0929-5313
Citations 
PageRank 
References 
7
1.02
3
Authors
2
Name
Order
Citations
PageRank
Christopher P. Fall1142.48
John Rinzel2459219.68