Name
Abstract | ||
|---|---|---|
Understanding the mechanisms involved in apoptosis has been an area of extensive study due to its critical role in the development and homeostasis of multi-cellular organisms. Our special interest lies in understanding the apoptosis of tumor cells which is mediated by novel potential drugs. Cephalostatin 1 is a marine compound that can induce apoptosis in leukemic cells in a dose- and time-dependent manner even at nano-molar concentrations using a recently discovered pathway that excludes the receptor-mediated pathway and which includes both the mitochondrial and endoplasmic reticulum pathways (Dirsch et al., Cancer Res 63:8869---8876, 2003; López-Antón et al., J Biol Chem 28:33078---33086, 2006). In this paper, the methods and tools of Petri net theory are used to construct, analyze, and validate a discrete Petri net model for cephalostatin 1-induced apoptosis. Based on experimental results and literature search, we constructed a discrete Petri net consisting of 43 places and 59 transitions. Standard Petri net analysis techniques such as structural and invariant analyses and a recently developed modularity analysis technique using maximal abstract dependent transition sets (ADT sets) were employed. Results of these analyses revealed model consistency with known biological behavior. The sub-modules represented by the ADT sets were compared with the functional modules of apoptosis identified by Alberghina and Colangelo (BMC Neurosci 7(Suppl 1):S2, 2006). |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1007/s11047-009-9153-9 | Natural Computing |
Keywords | Field | DocType |
Apoptosis,Cephalostatin 1,Discrete Petri net,Invariant analysis,Maximal abstract dependent transition sets (ADT sets),Modularity analysis,Structural analysis | Discrete mathematics,Petri net,Endoplasmic reticulum,Algorithm,Computational biology,Cephalostatin,Cephalostatin 1,Apoptosis,Mathematics | Journal |
Volume | Issue | ISSN |
10 | 3 | 1567-7818 |
Citations | PageRank | References |
2 | 0.36 | 6 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Eva M. Rodriguez | 1 | 2 | 0.36 |
| Anita Rudy | 2 | 2 | 0.36 |
| Ricardo C. Del Rosario | 3 | 2 | 0.36 |
| Angelika M. Vollmar | 4 | 2 | 0.36 |
| Eduardo R. Mendoza | 5 | 2 | 0.70 |