Name
Title | ||
|---|---|---|
GESTODIFFERENT: a Cytoscape plugin for the generation and the identification of gene regulatory networks describing a stochastic cell differentiation process. |
Abstract | ||
|---|---|---|
The characterization of the complex phenomenon of cell differentiation is a key goal of both systems and computational biology. GESTODIFFERENT is a Cytoscape plugin aimed at the generation and the identification of gene regulatory networks (GRNs) describing an arbitrary stochastic cell differentiation process. The (dynamical) model adopted to describe general GRNs is that of noisy random Boolean networks (NRBNs), with a specific focus on their emergent dynamical behavior. GESTODIFFERENT explores the space of GRNs by filtering the NRBN instances inconsistent with a stochastic lineage differentiation tree representing the cell lineages that can be obtained by following the fate of a stem cell descendant. Matched networks can then be analyzed by Cytoscape network analysis algorithms or, for instance, used to define (multiscale) models of cellular dynamics. |
Year | DOI | Venue |
|---|---|---|
2013 | 10.1093/bioinformatics/bts726 | BIOINFORMATICS |
Keywords | Field | DocType |
stochastic processes,gene regulatory networks,cell differentiation | Data mining,App store,Computer science,Cell Differentiation process,Stochastic process,Cellular differentiation,Theoretical computer science,Cell lineage,Network analysis,Bioinformatics,Plug-in,Gene regulatory network | Journal |
Volume | Issue | ISSN |
29 | 4 | 1367-4803 |
Citations | PageRank | References |
1 | 0.36 | 1 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Marco Antoniotti | 1 | 102 | 18.50 |
| Gary D Bader | 2 | 2365 | 266.51 |
| Giulio Caravagna | 3 | 156 | 16.46 |
| Silvia Crippa | 4 | 1 | 0.36 |
| Alex Graudenzi | 5 | 90 | 17.99 |
| Giancarlo Mauri | 6 | 2106 | 297.38 |