Name
Abstract | ||
|---|---|---|
The Acyl Carrier Protein (ACP) is a key element in the biosynthesis of fatty acids being responsible for the acyl group shuttling and delivery within a series of related enzymes. The molecular mechanism of the delivery process is poorly known, and its characterization is essential for indepth Understanding the biosynthetic machinery. A steered molecular dynamics approach has been applied to shed light oil the putative delivery pathway, suggesting the small alpha 3- helix act as gatekeeper for the transfer process. Preventing the delivery mechanism Would be an innovative strategy for the development of pathway-based antimalarial compounds. |
Year | DOI | Venue |
|---|---|---|
2008 | 10.1021/ci800297v | JOURNAL OF CHEMICAL INFORMATION AND MODELING |
Field | DocType | Volume |
Acyl carrier protein,Acyl group,Enzyme,Biochemistry,Chemistry,Protozoan Proteins,Plasmodium falciparum,Biosynthesis,Protein structure | Journal | 48 |
Issue | ISSN | Citations |
12 | 1549-9596 | 0 |
PageRank | References | Authors |
0.34 | 0 | 3 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Francesco Colizzi | 1 | 0 | 0.34 |
| Maurizio Recanatini | 2 | 18 | 6.57 |
| Andrea Cavalli | 3 | 10 | 2.82 |