Title
Harmonization of gene/protein annotations: towards a gold standard MEDLINE.
Abstract
Motivation: The recognition of named entities (NER) is an elementary task in biomedical text mining. A number of NER solutions have been proposed in recent years, taking advantage of available annotated corpora, terminological resources and machine- learning techniques. Currently, the best performing solutions combine the outputs from selected annotation solutions measured against a single corpus. However, little effort has been spent on a systematic analysis of methods harmonizing the annotation results and measuring against a combination of Gold Standard Corpora (GSCs). Results: We present Totum, a machine learning solution that harmonizes gene/protein annotations provided by heterogeneous NER solutions. It has been optimized and measured against a combination of manually curated GSCs. The performed experiments show that our approach improves the F-measure of state-of-the-art solutions by up to 10% (achieving approximate to 70%) in exact alignment and 22% (achieving approximate to 82%) in nested alignment. We demonstrate that our solution delivers reliable annotation results across the GSCs and it is an important contribution towards a homogeneous annotation of MEDLINE abstracts.
Year
DOI
Venue
2012
10.1093/bioinformatics/bts125
BIOINFORMATICS
Field
DocType
Volume
Data mining,Annotation,Information retrieval,Harmonization,Homogeneous,Computer science,Biomedical text mining,Protein Annotation,Bioinformatics,MEDLINE,Java
Journal
28
Issue
ISSN
Citations 
9
1367-4803
4
PageRank 
References 
Authors
0.45
20
5
Name
Order
Citations
PageRank
David Campos121910.69
Sérgio Matos241529.51
Ian Lewin324625.58
José Luis Oliveira476084.03
dietrich rebholzschuhmann5102375.06