Title
Fast algorithms for nonparametric population modeling of large data sets
Abstract
Population models are widely applied in biomedical data analysis since they characterize both the average and individual responses of a population of subjects. In the absence of a reliable mechanistic model, one can resort to the Bayesian nonparametric approach that models the individual curves as Gaussian processes. This paper develops an efficient computational scheme for estimating the average and individual curves from large data sets collected in standardized experiments, i.e. with a fixed sampling schedule. It is shown that the overall scheme exhibits a “client–server” architecture. The server is in charge of handling and processing the collective data base of past experiments. The clients ask the server for the information needed to reconstruct the individual curve in a single new experiment. This architecture allows the clients to take advantage of the overall data set without violating possible privacy and confidentiality constraints and with negligible computational effort.
Year
DOI
Venue
2009
10.1016/j.automatica.2008.06.003
Automatica
Keywords
Field
DocType
Nonparametric identification,Bayesian estimation,Glucose metabolism,Gaussian processes,Estimation theory
Data mining,Population,Data set,Computer science,Nonparametric statistics,Gaussian process,Sampling (statistics),Estimation theory,Population model,Bayes estimator
Journal
Volume
Issue
ISSN
45
1
0005-1098
Citations 
PageRank 
References 
7
0.72
4
Authors
4
Name
Order
Citations
PageRank
Pillonetto Gianluigi187780.84
Giuseppe De Nicolao273876.26
Marco Chierici3273.28
Claudio Cobelli4658113.31