Name
Abstract | ||
|---|---|---|
A model of the subthalamo-pallidal loop using integrate-and-fire neurons in conjunction with first order models of synaptic afferents, calcium and potassium currents, and a leaky sodium current exhibits activity similar to that recorded in the Subtlialamic nucleus of Parkinson patients undergoing stereotactic neurosurgery and Deep Brain Stimulation (DBS). In particular, by incorporating a negative feedback loop, the model produces inhibitory responses to individual DBS pulses and exhibits oscillations in the alpha and beta range (8-29Hz). Moreover, an increase in either DBS stimulus energy or GPe spontaneous activity causes the oscillatory behavior to subside. |
Year | DOI | Venue |
|---|---|---|
2007 | 10.1109/IJCNN.2007.4371436 | 2007 IEEE INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORKS, VOLS 1-6 |
Keywords | Field | DocType |
neurophysiology,ca,surgery,sodium,potassium,oscillations,negative feedback loop,na,calcium,k,negative feedback,first order | Alpha (ethology),Deep brain stimulation,Neuroscience,Neurophysiology,Pattern recognition,Computer science,Negative feedback,Inhibitory postsynaptic potential,Artificial intelligence,Stimulus (physiology),Subthalamic nucleus,Stimulation | Conference |
ISSN | Citations | PageRank |
2161-4393 | 0 | 0.34 |
References | Authors | |
1 | 2 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Stathis S. Leondopulos | 1 | 0 | 0.34 |
| Evangelia Micheli-Tzanakou | 2 | 14 | 4.50 |