Title
Validation and discovery from computational biology models.
Abstract
Simulation software is often a fundamental component in systems biology projects and provides a key aspect of the integration of experimental and analytical techniques in the search for greater understanding and prediction of biology at the systems level. It is important that the modelling and analysis software is reliable and that techniques exist for automating the analysis of the vast amounts of data which such simulation environments generate. A rigorous approach to the development of complex modelling software is needed. Such a framework is presented here together with techniques for the automated analysis of such models and a process for the automatic discovery of biological phenomena from large simulation data sets. Illustrations are taken from a major systems biology research project involving the in vitro investigation, modelling and simulation of epithelial tissue.
Year
DOI
Venue
2008
10.1016/j.biosystems.2008.03.010
Biosystems
Keywords
Field
DocType
Agent-based modelling,Simulation,X-machines,Validation and testing,Parallel computation
Data set,Simulation software,Computer science,Software,Computational science,Artificial intelligence,Verification and validation of computer simulation models,Software engineering,Analysis software,Systems biology,Epithelial tissue,Modelling biological systems,Machine learning
Journal
Volume
Issue
ISSN
93
1
0303-2647
Citations 
PageRank 
References 
7
1.20
2
Authors
5
Name
Order
Citations
PageRank
Mariam Kiran112117.83
Simon Coakley21208.87
Neil Walkinshaw334527.27
phil mcminn4238497.58
Mike Holcombe551054.25