Title
Age-dependent brain activation during forward and backward digit recall revealed by fMRI.
Abstract
In this study, brain activation associated with forward and backward digit recall was examined in healthy old and young adults using functional MRI. A number of areas were activated during the recall. In young adults, greater activation was found in the left prefrontal cortex (BA9) and the left occipital visual cortex during backward digit recall than forward digit recall. In contrast, the activation in the right inferior frontal gyrus (BA 44/45) was more extensive in forward digit recall than in backward digit recall. In older adults, backward recall generated stronger activation than forward recall in most areas, including the frontal, the parietal, the occipital, and the temporal cortices. In the backward recall condition, the right inferior frontal gyrus (BA44/45) showed more activation in the old group than in the young group. These results suggest that different neural mechanisms may be involved in forward and backward digit recall and brain functions associated with these two types of recall are differentially affected by aging.
Year
DOI
Venue
2005
10.1016/j.neuroimage.2005.01.022
NeuroImage
Keywords
Field
DocType
Working memory,Short-term memory,Aging,Prefrontal cortex,fMRI
Developmental psychology,Neuroscience,Levels-of-processing effect,Visual cortex,Numerical digit,Working memory,Prefrontal cortex,Cognitive psychology,Psychology,Young adult,Short-term memory,Recall
Journal
Volume
Issue
ISSN
26
1
1053-8119
Citations 
PageRank 
References 
3
1.01
2
Authors
9
Name
Order
Citations
PageRank
Xiwen Sun1193.47
Xiaochu Zhang2175.79
Xiangchuan Chen3213.07
Peng Zhang4126.86
Min Bao582.29
Daren Zhang6345.65
Jing Chen731.01
Sheng He8122.67
Xiaoping Hu9172.51