Paper Info
Title
Cdc45: the missing RecJ ortholog in eukaryotes?
Abstract
DNA replication is one of the most ancient of cellular processes and functional similarities among its molecular machinery are apparent across all cellular life. Cdc45 is one of the essential components of the eukaryotic replication fork and is required for the initiation and elongation of DNA replication, but its molecular function is currently unknown. In order to trace its evolutionary history and to identify functional domains, we embarked on a computational sequence analysis of the Cdc45 protein family. Our findings reveal eukaryotic Cdc45 and prokaryotic RecJ to possess a common ancestry and Cdc45 to contain a catalytic site within a predicted exonuclease domain. The likely orthology between Cdc45 and RecJ reveals new lines of enquiry into DNA replication mechanisms in eukaryotes.
Year
DOI
Venue
2011
10.1093/bioinformatics/btr332
BIOINFORMATICS
Field
DocType
Volume
Protein family,Eukaryote,Biology,Origin recognition complex,Exonuclease,Bioinformatics,DNA replication,Genetics,Abstract Summary,CMG complex,Sequence analysis
Journal
27
Issue
ISSN
Citations 
14
1367-4803
0
PageRank 
References 
Authors
0.34
6
2
Name
Order
Citations
PageRank
Luis Sánchez-Pulido123.16
Chris P. Ponting2733283.28