Name
Title | ||
|---|---|---|
Mapping Hippocampal Degeneration In 400 Subjects With A Novel Automated Segmentation Approach |
Abstract | ||
|---|---|---|
We automatically segmented the hippocampus in 400 brain MRI scans from the Alzheimer's Disease (AD) Neuroimaging Initiative, combining AdaBoost with a novel model, the Auto Context Model (ACM). Trained on 21 hand-labeled segmentations, ACM created binary hippocampus maps in 100 controls, 200 with mild cognitive impairment (MCI), and 100 AD subjects, (age: 75.8+/-6.6SD). A radial atrophy mapping technique computed average parametric surface models and local statistics of atrophy. We visualized correlations between regional atrophy and diagnosis (MCI v. controls: p = 0.008; MCI v. AD: p = 0.001), mini-mental state exam scores, and clinical dementia rating scores (CDR; all p < 0.0001, corrected). Based on false discovery rate curves in gradually reduced samples, 40 subjects were sufficient to correlate atrophy and CDR scores; MCI and AD were distinguishable with N = 304. |
Year | DOI | Venue |
|---|---|---|
2008 | 10.1109/ISBI.2008.4541001 | 2008 IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO, VOLS 1-4 |
Keywords | Field | DocType |
AdaBoost, Alzheimer's Disease, hippocampal segmentation, magnetic resonance imaging | Nuclear medicine,Computer science,Artificial intelligence,Neuroimaging,Hippocampal formation,Pathology,Clinical Dementia Rating,False discovery rate,Pattern recognition,Alzheimer's Disease Neuroimaging Initiative,Atrophy,Hippocampus,Magnetic resonance imaging | Conference |
ISSN | Citations | PageRank |
1945-7928 | 4 | 0.51 |
References | Authors | |
4 | 13 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Jonathan H. Morra | 1 | 224 | 13.23 |
| Zhuowen Tu | 2 | 3663 | 215.79 |
| Liana G. Apostolova | 3 | 112 | 8.24 |
| Amity E. Green | 4 | 170 | 9.13 |
| Christina Avedissian | 5 | 169 | 10.30 |
| Sarah Madsen | 6 | 131 | 13.50 |
| Neelroop Parikshak | 7 | 176 | 10.91 |
| Xue Hua | 8 | 361 | 25.75 |
| Arthur W. Toga | 9 | 3128 | 261.46 |
| Clifford R Jack | 10 | 769 | 59.51 |
| Norbert Schuff | 11 | 374 | 26.44 |
| Michael Weiner | 12 | 22 | 2.99 |
| Paul Thompson | 13 | 3860 | 321.32 |