Title
ONTOFUSION: Ontology-based integration of genomic and clinical databases
Abstract
ONTOFUSION is an ontology-based system designed for biomedical database integration. It is based on two processes: mapping and unification. Mapping is a semi-automated process that uses ontologies to link a database schema with a conceptual framework—named virtual schema. There are three methodologies for creating virtual schemas, according to the origin of the domain ontology used: (1) top-down—e.g. using an existing ontology, such as the UMLS or Gene Ontology—, (2) bottom-up—building a new domain ontology— and (3) a hybrid combination. Unification is an automated process for integrating ontologies and hence the database to which they are linked. Using these methods, we employed ONTOFUSION to integrate a large number of public genomic and clinical databases, as well as biomedical ontologies.
Year
DOI
Venue
2006
10.1016/j.compbiomed.2005.02.004
Computers in Biology and Medicine
Keywords
DocType
Volume
Ontologies,Biomedical informatics,Biomedical ontologies,Database integration,Ontology unification
Journal
36
Issue
ISSN
Citations 
7
0010-4825
39
PageRank 
References 
Authors
1.98
11
7
Name
Order
Citations
PageRank
david perezrey113520.28
V Maojo2896.65
Miguel García-Remesal312813.75
Raúl Alonso-Calvo410714.64
Holger Billhardt537236.86
F Martin-Sanchez61007.62
António Sousa Pereira7888.21