Name
Abstract | ||
|---|---|---|
The Animal QTLdb was created to warehouse, compare and facilitate meta-analyses of QTL results from multiple, independent experiments. To date, more than 13,930 cattle, chicken, pigs and sheep QTL have been curated into the database. A number of meta-analysis studies have been carried out in several livestock species, but the results are not readily comparable due to the use of different models and scenarios for statistical inference in these studies. Each analysis is not only time consuming, but also not trivial for a biologist to rerun when new data are added. On the other hand, the continuing rapid increase of QTL data demands a better and faster way to combine QTL data in order to speed up the discovery of causal variants that underlie each QTL. We have implemented two simple, non-parametric meta-analysis methods to perform real-time QTL meta-analysis on the fly. One method is a simple plot of QTL counts at each centiMorgan (cM) along a chromosome; the other method is a kernel density distribution plot of such counts. In both methods, the presence of QTL is computed to indicate the most likely QTL locations supported by available data. This function is available on the QTLdb when users visualize a QTL relative to a chromosome of cattle, chicken, pig or sheep. We are actively working to implement more practical and robust meta-analysis methods to facilitate better focused QTL data mining. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1145/2147805.2147874 | BCB |
Keywords | Field | DocType |
real-time qtl meta-analysis,available data,animal qtldb,likely qtl location,qtl result,sheep qtl,qtl data,non-parametric meta-analysis method,new data,meta-analysis study,qtl data mining,kernel density,data mining,statistical inference,real time,quantitative trait loci,meta analysis | Centimorgan,Quantitative trait locus,Biology,Inclusive composite interval mapping,On the fly,Family-based QTL mapping,Statistical inference,Computational biology,Genetics,Meta-analysis,Kernel density estimation | Conference |
Citations | PageRank | References |
1 | 0.54 | 1 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Zhi-Liang Hu | 1 | 86 | 6.91 |
| Xiao-Lin Wu | 2 | 6 | 1.61 |
| James M Reecy | 3 | 64 | 6.73 |