Paper Info
Title
Scroll waves in 3D virtual human atria: a computational study
Abstract
Atrial fibrillation (AF) induced electrical remodelling of ionic channels shortens action potential duration and reduces atrial excitability. Experimental data of AF-induced electrical remodelling (AFER) from two previous studies on human atrial myocytes were incorporated into a human atrial cell computer model to simulate their effects on atrial electrical behaviour. The dynamical behaviors of excitation scroll waves in an anatomical 3D homogenous model of human atria were studied for control and AF conditions. Under control condition, scroll waves meandered in large area and became persistent when entrapped by anatomical obstacles. In this case, a mother rotor dominated atrial excitation. Action potentials from several sites behaved as if the atrium were paced rapidly. Under AF conditions, AFER increased the stability of re-entrant scroll waves by reducing meander. Scroll wave break up leads to wavelets underpinning sustained chronic AF. Our simulation results support the hypothesis that AF-induced electrical remodelling perpetuates and sustains AF.
Year
DOI
Venue
2007
10.1007/978-3-540-72907-5_14
FIMH
Keywords
Field
DocType
excitation scroll wave,human atrial cell computer,virtual human atrium,af condition,atrial excitability,atrial excitation,af-induced electrical remodelling,chronic af,atrial electrical behaviour,human atrial myocytes,electrical remodelling,computational study,computer model,action potential,virtual human,wave breaking
Scroll,Atrial fibrillation,Atrium (architecture),Simulation,Action potential duration,Chronic AF,Mechanics,Ionic Channels,Physics
Conference
Volume
ISSN
Citations 
4466
0302-9743
2
PageRank 
References 
Authors
0.47
2
6
Name
Order
Citations
PageRank
Sanjay Kharche1104.21
Gunnar Seemann221248.50
Joanna Leng361.04
Arun V. Holden45220.71
Clifford J. Garratt531.44
Henggui Zhang610551.88